The Cell-IN initiative joins the commercialization projects carried out at the IPC PAS.
Cell-IN offers a reagent allowing the introduction of various types of macromolecules (from
polymers, proteins, to DNA molecules) into mammalian cells.
The Cell-IN product works by disintegrating intracellular vesicles under osmotic shock. During
disintegration, the probes inside the vesicles are released into the cell. Cell-IN was developed as an
agent supporting this process – the nanostructure of the working solution proved to be crucial for the
efficiency of introducing the cargos into the cytoplasm.
The favorable price characterizes Cell-IN products – due to low production costs and the possibility of
choosing the product size adapted to specific experimental conditions.
Based on previous studies, Cell-IN has been validated for a wide range of probes (dyes, polymers,
proteins, nucleic acids, nanoparticles) as well as cell types (normal, cancer, epithelial, mesenchymal
cells). Cell-IN allows the introduction of cargo sizes ranging from single nanometers to more than 100
nm, which is a distinguishing feature in the market. Furthermore, the high viability (>80%) of cells
treated with the Cell-IN procedure has been confirmed up to 3 days after the procedure.
The method of obtaining the product has already been submitted to the Patent Office: P.437320
One PhD Student position and 2 Postdoctoral Researcher positions are available in the Institute of Physical Chemistry PAS within Virtual Research Institute (VIB) – Łukasiewicz Research Network – PORT Polish Center for Technology Development, Co-Financed by the Polish Science Fund, project no. WIB-1/2020-O11, entitled “Horizon for Excellence in messenger RNA applications in immunoOncology”, led by Prof. Andrzej Dziembowski – Leader of WIB_HERO project, Prof. Robert Hołyst – Team Leader of IChF Group in WIB_HERO project.
PhD Student: here