We are different, but we all do great
Science & we have a lot of fun of doing it!

SOFT CONDENSED MATTER
ROBERT HOŁYST GROUP

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She is in TOP5 finalists in this international competition You can support her by voting (1 vote per one day) to the 15th of December 2021. The link in the desription
Our project „Nanoplastics in living cells" received funding of ca. PLN 2 MLN. Development of a method to assess the impact of plastic nanoparticles on transport onat the cellular level is the main focus of the project.
"It was my great pleasure to share with you, Marta, one office. Thank you for all our valuable conversations. I am really proud of you." - prof. Robert Hołyst Marta - we are so proud of you & we wish you all the best in your scientific way!

SOFT CONDENSED MATTER ROBERT HOŁYST GROUP

We are one of the scientific groups from IPC PAS in Warsaw, Poland. Our main goal is to understand and expand knowledge about soft and living matter in vivo and in vitro conditions. We are focus on the transport phenomena in complex liquid, quantitative biophysical chemistry & non-equilibrium processes.

Our Group involves specialists from different science fields, including physicists, biologists, chemists, engineers, and biotechnologists. We are enthusiasts of interdisciplinary projects because we believe that the most interesting things happen in places where two or three fields merge. We are not afraid to think big because the sky is the limit.

The equilibrium constant (K) of biochemical complex formation in aqueous buffers with high concentration (>20 wt %) of nonionic compounds can vary by orders of magnitude in comparison with the K in a pure buffer. The precise molecular mechanisms of these profound changes are not known.
Quantitative description of biochemical processes inside living cells and at single-molecule levels remains a challenge at the forefront of modern instrumentation and spectroscopy. This paper demonstrates such single-cell, single-molecule analyses performed to study the mechanism of action of olaparib – an up-to-date, FDA-approved drug for germline-BRCA mutated metastatic breast cancer.
Specific lipid environments are necessary for the establishment of protein signaling platforms in membranes, yet their origin has been highly debated. We present a continuum, exactly solvable model of protein induced local demixing of lipid membranes.
We simulated the Brownian diffusion and reaction-diffusion processes to study molecular rebinding’s influence on the reaction rates of bimolecular reactions. We found that the number of rebindings, Nreb , is proportional to the target’s size and inversely proportional to the diffusion coefficient D and simulation time-step ∆t.
Using nanosized metal substrates, surface-enhanced Raman scattering (SERS) is a tool for improving the Raman signal of biomolecules. For detection, SERS has gained much popularity and an important role in determining chemical composition.
Targeting cap-dependent translation initiation is one of experimental approaches that could lead to the development of novel anti-cancer therapies. Synthetic dinucleoside 5’, 5’-triphosphates cap analogs are potent antagonists of eukaryotic translation initiation factor 4E (eIF4E) in vitro and could counteract elevated levels of eIF4E in cancer cells;