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Science & we have a lot of fun of doing it!

SOFT CONDENSED MATTER
ROBERT HOŁYST GROUP

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The program, which lasts six months, includes a series of lectures and trainings aimed at acquiring the skills and knowledge necessary to start your own start-up. Congratulations Aneta! We are very proud of you.
Today is a big day for science. Young minds were awarded in the contest like no other. The scientists, visionaries, and dreamers, not hesitating to ask "What if?" achieved the prizes in the Dream Chemistry Award competition in Warsaw, Poland.

SOFT CONDENSED MATTER ROBERT HOŁYST GROUP

We are one of the scientific groups from IPC PAS in Warsaw, Poland. Our main goal is to understand and expand knowledge about soft and living matter in vivo and in vitro conditions. We are focus on the transport phenomena in complex liquid, quantitative biophysical chemistry & non-equilibrium processes.

Our Group involves specialists from different science fields, including physicists, biologists, chemists, engineers, and biotechnologists. We are enthusiasts of interdisciplinary projects because we believe that the most interesting things happen in places where two or three fields merge. We are not afraid to think big because the sky is the limit.

Bevacizumab is a biological drug that is now extensively studied in clinics against various types of cancer. Although bevacizumab’s action is preferably extracellular, there are reports suggesting its internalization into cancer cells, consequently decreasing its therapeutic potential. Here we are solving this issue by applying fluorescence correlation spectroscopy in living cells.
The reaction kinetics between like-charged compounds in water is extremely slow due to Coulomb repulsions. Here, we demonstrate that by screening these interactions and, in consequence, increasing the local concentration of reactants, we boost the reactions by many orders of magnitude. The reaction between negatively charged Coenzyme A molecules accelerates ~5 million-fold using cationic micelles. That is ~104 faster kinetics than in 0.5 M NaCl, although the salt is ~106 more concentrated.
Most experimental procedures applied in modern biology involve cargo delivering into cells. One of the ways to cargo introduction is osmotic-mediated intracellular vesicle swelling. However, its widespread use was hindered due to cargo size (<10 nm) and cell-type-related restrictions. We addressed the issue of the composition of colloidal loading solution to enhance the efficiency of cellular delivery.
Biocompatible polyacrylamide gel and core–shell nanoparticles (NPs) were synthesized using a one-step electrochemically initiated gelation. Constant-potential electrochemical decomposing of ammonium persulfate initiated the copolymerization of N-isopropyl acrylamide, methacrylic acid, and N,N′-methylenebisacrylamide monomers.
Nitrophenols (NPs) are hazardous pollutants found in various environmental matrices, including ambient fine particulate matter (PM2.5), agricultural residues, rainwater, wildfires, and industrial wastes. This study showed for the first time the effect of three pure nitrophenols and their mixture on human lung cells to provide basic understanding of the NP influence on cell elements and processes.
We investigate the thermal relaxation of an ideal gas from a nonequilibrium stationary state. The gas is enclosed between two walls, which initially have different temperatures. After making one of the walls adiabatic, the system returns to equilibrium.